Title:Antisense Agents against Antibiotic-resistant Bacteria
Volume: 23
Issue: 15
Author(s): Javad Nezhadi, Sepehr Taghizadeh, Ehsaneh Khodadadi, Mehdi Yousefi, Khudaverdi Ganbarov, Bahman Yousefi, Hamed Ebrahimzadeh Leylabadlo, Mohammad Asgharzadeh, Asghar Tanomand, Fahimeh Kazeminava and Hossein Samadi Kafil*
Affiliation:
- Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Keywords:
Antibiotic resistance, nucleic acids analogs, PNAs, PPMOs, LNAs, bases.
Abstract: The dramatically increasing levels of antibiotic resistance are being seen worldwide
and are a significant threat to public health. Antibiotic and drug resistance is seen in various
bacterial species. Antibiotic resistance is associated with increased morbidity and mortality and
increased treatment costs. Antisense-related technologies include oligonucleotides that interfere
with gene transcription and expression; these oligonucleotides can help treat antibiotic-resistant
bacteria. The important oligonucleotides include Peptide Nucleic Acids (PNAs),
Phosphorodiamidate Morpholino Oligomers (PPMOs), and Locked Nucleic Acids (LNAs).
Typically, the size of these structures (oligonucleotides) is 10 to 20 bases. PNAs, PPMOs, and
LNAs are highlighted in this review as targets for genes that cause the gene to be destroyed and
impede bacterial growth. These results open a new perspective for therapeutic intervention.
Future studies need to examine different aspects of antisense agents, such as the safety, toxicity,
and pharmacokinetic properties of antisense agents in clinical treatment.