Title:Gastroenteropancreatic Neuroendocrine Neoplasms (GEP NENs): The
Role of Checkpoint Inhibitors
Volume: 22
Issue: 8
关键词:
胃肠胰、神经内分泌、肿瘤、检查点抑制剂、免疫治疗、PD-L1。
摘要:
Background: The treatment options for GEP-NENs include various drugs and are based
on grading, morphology, and location of the primary.
Objective: The aim of our work is to investigate the clinical impact of new immune checkpoint inhibitors
in order to define a new possible strategy of use within GEP-NENs.
Methods: A scientific literature search from 2015 to January 2020 was performed using PubMed
and Embase: reviews and prospective or retrospective studies with a minimum of twenty patients
were selected; conference proceedings were included.
Results: Several studies have been conducted to assess the role of immune checkpoint inhibitors in
NENs, but nowadays, the current knowledge in this field is mainly based on phase I-II studies. Immunotherapy
showed limited antitumor activity, but a higher response rate was reported in poor-differentiated
neuroendocrine tumors. No specific biomarkers were identified for patient selection and
response assessment.
Conclusion: Immunotherapy appears as a powerful possibility to help our patients, but nowadays,
we see many gaps in this field. We must balance therapeutic possibilities offered by precision oncology
with an understanding of the limitations of the application of testing and treatment in clinical
practice. Future efforts should focus on research of the best patients to a candidate for immunotherapy
in terms of disease characteristics and previous treatments and how to select them
with accurate biomarkers.
