Title:Determination of Both TP53 Mutation Status and the Amount of p53
Protein has Limited Diagnostic Importance for Patients with Ovarian
Cancer
Volume: 29
Issue: 24
Author(s): Sebastian M. Klein, Maria Bozko, Astrid Toennießen, Nisar P. Malek and Przemyslaw Bozko*
Affiliation:
- Department of Internal Medicine I, Universitätsklinikum Tübingen, Tübingen, Germany
Keywords:
Ovarian cancer, tumor suppressors, TP53, p53, patient survival, prognostic laboratory parameters.
Abstract:
Background: Ovarian cancer is one of the most aggressive types of gynecologic
cancers. Many patients have a relapse within two years after diagnosis and subsequent
therapy. Among different genetic changes generally believed to be important for the development
of cancer, TP53 is the most common mutation in the case of ovarian tumors.
Objective: Our work aims to analyze the outcomes of different comparisons based on the
overall survival of ovarian cancer patients, the determination of TP53 status and the
amount of p53 protein in tumor tissues.
Methods: We analyzed and compared a collective of 436 ovarian patients’ data. The extracted
data include TP53 mutation status, p53 protein level and information on the overall
survival. Values for p53 protein level in dependence of the TP53 mutation status were
compared using the Independent Samples t-Test. Survival analyses were displayed by Kaplan-
Meier plots, using the log-rank test to check for statistical significance.
Results: We have not found any statistically significant correlations between the determination
of TP53 status or the amount of p53 protein in tumor tissues and the overall survival
of ovarian cancer patients.
Conclusion: In ovarian tumors the determination of both the TP53 status as well as the
p53 protein amount has only limited diagnostic importance.
