Title:Neuroprotective Potential of Bacopa monnieri: Modulation of Inflammatory
Signals
Volume: 22
Issue: 3
Author(s): Erica Costantini, Srinivas Jarlapoodi, Federica Serra, Lisa Aielli, Haroon Khan, Tarun Belwal, Katia Falasca and Marcella Reale*
Affiliation:
- Department
of Innovative Technologies in Medicine and Dentistry, University "G.d’Annunzio", Via dei Vestini 66100
Chieti, Italy
Keywords:
Neuroprotection, inflammation, cytokines, metalloproteinases, cyclooxygenase, inducible nitric oxide synthase.
Abstract:
Background: To date, much evidence has shown the increased interest in natural
molecules and traditional herbal medicine as alternative bioactive compounds to fight many inflammatory
conditions, both in relation to immunomodulation and in terms of their wound healing potential.
Bacopa monnieri is a herb that is used in the Ayurvedic medicine tradition for its anti-inflammatory
activity.
Objective: In this study, we evaluate the anti-inflammatory and regenerative properties of the Bacopa
monnieri extract (BME) in vitro model of neuroinflammation.
Methods: Neuronal SH-SY5Y cells were stimulated with TNFα and IFNγ and used to evaluate the
effect of BME on cell viability, cytotoxicity, cytokine gene expression, and healing rate.
Results: Our results showed that BME protects against the Okadaic acid-induced cytotoxicity in
SH-SY5Y cells. Moreover, in TNFα and IFNγ primed cells, BME reduces IL-1β, IL-6, COX-2,
and iNOS, mitigates the mechanical trauma injury-induced damage, and accelerates the healing of
wounds.
Conclusion: This study indicates that BME might become a promising candidate for the treatment
of neuroinflammation.
