Title:Recent Developments of Coumarin-based Hybrids in Drug Discovery
Volume: 22
Issue: 4
Author(s): Dongguo Xia, Hao Liu, Xiang Cheng, Manikantha Maraswami, Yiting Chen*Xianhai Lv*
Affiliation:
- Fujian Provincial University Engineering
Research Center of Green Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, China
- School of Science, Anhui Agricultural University, Hefei, 230036, China
Keywords:
Coumarin, Anticancer, Antimicrobial, Anti-Alzheimer, Anti-inflammatory, Inhibitors.
Abstract: Coumarin scaffold is a highly significant O-heterocycle, namely benzopyran-2-ones,
which form an elite class of naturally occurring compounds with promising therapeutic perspectives.
Based on its broad spectrum of biological activities, the privileged coumarin scaffold is applied
to medicinal and pharmacological treatments by several rational design strategies and approaches.
Structure-activity relationships of the coumarin-based hybrids with various bioactivity
fragments revealed significant information toward the further development of highly potent and selective
disorder therapeutic agents. The molecular docking studies between coumarins and critical
therapeutic enzymes demonstrated a mode of action by forming noncovalent interactions with
more than one receptor, further rationally confirming information about structure-activity relationships.
This review summarizes recent developments related to coumarin-based hybrids with other
pharmacophores aiming at numerous feasible therapeutic enzymatic targets in order to combat various
therapeutic fields, including anticancer, antimicrobic, anti-Alzheimer, anti-inflammatory activities.