Title:Fibrinolytic Enzyme - An Overview
Volume: 23
Issue: 11
Author(s): Parveen Abdul Rahim and Devika Rengaswamy*
Affiliation:
- Department of Biotechnology, Aarupadai Institute of Technology, Vinayaka Missions University, Chennai, India
Keywords:
Enzyme, fibrinolytic agents, biocatalyst, cardiovascular disease, therapeutic potential, fibrinolysis.
Abstract: Cardiovascular diseases, like coronary heart disease or artery disorders (arteriosclerosis,
including artery solidification), heart failure (myocardial infarction), arrhythmias, congestive heart
condition, stroke, elevated vital signs (hypertension), rheumatic heart disorder, and other circulatory
system dysfunctions are the most common causes of death worldwide. Cardiovascular disorders
are treated with stenting, coronary bypass surgery grafting, anticoagulants, antiplatelet agents, and
other pharmacological and surgical procedures; however, these have limitations due to their adverse
effects. Fibrinolytic agents degrade fibrin through enzymatic and biochemical processes.
There are various enzymes that are currently used as a treatment for CVDs, like streptokinase,
nattokinase, staphylokinase, urokinase, etc. These enzymes are derived from various sources, like
bacteria, fungi, algae, marine organisms, plants, snakes, and other organisms. This review deals
with the fibrinolytic enzymes, their mechanisms, sources, and their therapeutic potential.