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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Mini-Review Article

An Update on Arginase Inhibitors and Inhibitory Assays

Author(s): Jason Muller, Rym Attia, Andy Zedet, Corine Girard and Marc Pudlo*

Volume 22, Issue 15, 2022

Published on: 27 April, 2022

Page: [1963 - 1976] Pages: 14

DOI: 10.2174/1389557522666211229105703

Price: $65

Abstract

Arginase, which converts arginine into ornithine and urea, is a promising therapeutic target. Arginase is involved in cardiovascular diseases, parasitic infections and through a critical role in immunity, in some cancers. There is a need to develop effective arginase inhibitors and therefore efforts to identify and optimize new inhibitors are increasing. Several methods of evaluating arginase activity are available, but few directly measure the product. Radiometric assays need to separate urea and dying reactions require acidic conditions and sometimes heating. Hence, there are a variety of different approaches available, and each approach has its own limits and benefits. In this review, we provide an update on arginase inhibitors, followed by a discussion on available arginase assays and alternative methods, focusing on the intrinsic biases and parameters that are likely to impact results.

Keywords: Arginase, inhibitors, evaluation, assays, colorimetric, radiometric, cell culture.

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