Title:The Emerging Role of Nanosuspensions for Drug Delivery and Stability
Volume: 11
Issue: 4
Author(s): Hitesh Kumar Dewangan*
Affiliation:
- University Institute of Pharma Sciences (UIPS), Chandigarh University NH-95, Chandigarh Ludhiana Highway, Mohali
Punjab, India
Keywords:
Nano-suspension, drug delivery, bioavailability, cell membrane, medicinal compounds, nanoparticles.
Abstract: Poor solubility of some medicinal compounds is a serious challenge that can be addressed
by using a nano-suspension for improved delivery. The nanoparticles enhance the bioavailability
along with the aqueous solubility of the drug, which is accomplished by increasing the active
surface area of the drug. The gained attention of the nanosuspension is due to its stabilization
facility, which is achieved by polymers, such as polyethylene glycol (PEG), having a particular
size range of 10 - 100 nm. Hence, these nanoparticles have the capacity of binding to the targeted
with very low damage to the healthy tissues. These are prepared by various methods, such as
milling, high-pressure homogenization, and emulsification, along with melt emulsification. Moreover,
surface modification and solidification have been used to add specific properties to the advanced
therapies as post-processing techniques. For many decades, it has been known that water
solubility hampers the bioavailability and not all drugs are water-soluble. In order to combat this
obstacle, nanotechnology has been found to be of specific interest. For elevating the bioavailability
by increasing the dissolution rate, the methodology of reduction of the associated drug particles into
their subsequent submicron range is incorporated. For oral and non-oral administration, these
nanosuspension formulations are used for the delivery of drugs.
