Title:Regulation of Tumor Immune Microenvironment by Sphingolipids and
Lysophosphatidic Acid
Volume: 23
Issue: 6
Author(s): Supriya Vishwakarma, Neha Arya and Ashok Kumar*
Affiliation:
- Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Saket Nagar, Bhopal 462020, India
Keywords:
Tumor microenvironment, tumor-infiltrating immune cells, tumor-infiltrating lymphocytes, sphingosine-1-phosphate, lysophosphatidic acid, immune system.
Abstract: The tumor microenvironment (TME) consists of cancer cells that interact with stromal
components such as the extracellular matrix, blood, and lymphatic networks, fibroblasts, adipocytes,
and the cells of the immune system. Further, the tumor immune microenvironment, majorly
represented by the tumor-infiltrating immune cells (TIIC), plays an important role in cancer therapeutics
and patient prognosis. In fact, a high density of TIICs within the tumor microenvironment
is known to be associated with better outcomes in several types of cancers. Towards this, two bioactive
lipid molecules, lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), regulate the
homing of immune cells to the TME. In the present review, we will uncover the role of LPA and
S1P signaling in the tumor immune environment, highlighting the latest progress in this field.