Title:Inflammation in the CNS: Understanding Various Aspects of the Pathogenesis
of Alzheimer's Disease
Volume: 19
Issue: 1
Author(s): Julia Doroszkiewicz*, Piotr Mroczko and Agnieszka Kulczyńska-Przybik*
Affiliation:
- Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Bialystok, Poland
- Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Bialystok, Poland
Keywords:
neuroinflammation, Alzheimer's disease, dementia disorders, biomarkers, neurodegeneration, chemokines, interleukins
Abstract: Alzheimer’s disease is a progressive and deadly neurodegenerative disorder and one of
the most common causes of dementia globally. Current, insufficiently sensitive and specific methods
of early diagnosing and monitoring this disease prompt a search for new tools. Numerous literature
data have indicated that the pathogenesis of Alzheimer’s disease (AD) is not limited to the neuronal
compartment but involves various immunological mechanisms. Neuroinflammation has been
recognized as a very important process in AD pathology. It seems to play pleiotropic roles, both
neuroprotective and neurodegenerative, in the development of cognitive impairment depending on
the stage of the disease. Mounting evidence demonstrates that inflammatory proteins could be considered
biomarkers of disease progression. Therefore, the present review summarizes the role of
some inflammatory molecules and their potential utility in detecting and monitoring dementia
severity. This paper also provides a valuable insight into new mechanisms leading to the development
of dementia, which might be useful in discovering possible anti-inflammatory treatment.
