摘要
癌症是一个具有挑战性的医学问题,影响着全世界数百万人。癌细胞的耐药性是更复杂的治疗完全繁荣的主要障碍之一。多孔形成肽是一种天然的防御系统蛋白,是几乎所有生物的抗细菌和抗真菌药物,也是一种新型的杀瘤肽。PFPs方法需要将可溶性肽主要组装在目标细胞膜上,形成潜在的致死孔。利用天然PFPs或其合成衍生物诱导肿瘤细胞的物理损伤,可以克服肿瘤细胞的耐药机制。考虑到肽类药物主要由于易于合成和安全性而涉及制药市场的很大一部分,作为一组抗癌肽,评估其特性提供了一个模型系统似乎是一种有价值的方法。在这里,重点介绍了PFPs的作用模式及其抗癌机制,然后讨论了使用不同来源的PFPs以及应用各种策略来获得PFPs对癌细胞的选择性作用的抗癌研究。本文还提出了这些有前景的生物活性分子在癌症治疗中的挑战和未来展望。
关键词: 癌症治疗,成孔肽,细胞穿透肽,细胞死亡,联合治疗,靶向输送。
Current Medicinal Chemistry
Title:Pore-forming Peptides: A New Treatment Option for Cancer
Volume: 29 Issue: 23
关键词: 癌症治疗,成孔肽,细胞穿透肽,细胞死亡,联合治疗,靶向输送。
摘要: Cancer, a challenging medical problem, affects millions of people around the world. Cancer cell resistance is one of the main drawbacks in the complete prosperity of even more sophisticated therapies. Pore-forming peptides (PFPs), a group of natural defense system proteins are used by nearly all living organisms as anti-bacterial and anti-- fungal agents, and could also be regarded as novel tumoricidal peptides. PFPs approach entails using soluble peptides by assembling them mainly on the target cell membrane and forming potential death-causing pores. Physical damage induction by natural PFPs or their synthetic derivatives could conquer the resistance mechanisms of tumor cells. Given that peptide drugs involve a significant proportion of the pharmaceutical market primarily because of easy synthesis and safety, evaluating this nature provided a model system as a group of anticancer peptides seems a valuable approach. Here, the mode of action of PFPs and their anticancer mechanism are highlighted, followed by addressing the anticancer studies using PFPs from different sources along with various strategies applied to obtain selective action of PFPs against cancer cells. Challenges and future perspectives of these promising bioactive molecules in cancer treatment are also provided.
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Cite this article as:
Pore-forming Peptides: A New Treatment Option for Cancer, Current Medicinal Chemistry 2022; 29 (23) . https://dx.doi.org/10.2174/0929867328666211126150055
DOI https://dx.doi.org/10.2174/0929867328666211126150055 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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