Title:Recent Advances in Biotransformation by Cunninghamella Species
Volume: 22
Issue: 13
Author(s): Manoela Daiele Gonçalves*, Fernanda Tomiotto-Pellissier, Ricardo Luís Nascimento de Matos, João Paulo Assolini, Bruna Taciane da Silva Bortoleti, Virginia Marcia Concato, Taylon Felipe Silva, Janice Aparecida Rafael, Wander Rogério Pavanelli, Ivete Conchon-Costa and Nilton Syogo Arakawa
Affiliation:
- Laboratory of Biotransformation and Phytochemistry, Department of Chemistry, Center of Exact Sciences and Department of Pharmaceutical Sciences, Center of Health Sciences, State University of Londrina,Brazil
Keywords:
Filamentous fungi, metabolism, chemical modifications, green chemical, cytochrome P450, xenobiotics.
Abstract: The goal of the biotransformation process is to develop structural changes and generate new chemical
compounds, which can occur naturally in mammalian and microbial organisms, such as filamentous fungi, and represent
a tool to achieve enhanced bioactive compounds. Cunninghamella spp. is among the fungal models most widely
used in biotransformation processes at phase I and II reactions, mimicking the metabolism of drugs and xenobiotics
in mammals and generating new molecules based on substances of natural and synthetic origin. Therefore, the goal
of this review is to highlight the studies involving the biotransformation of Cunninghamella species between January
2015 and March 2021, in addition to updating existing studies to identify the similarities between the human metabolite
and Cunninghamella patterns of active compounds, with related advantages and challenges, and providing new
tools for further studies in this scope.