Title:Chromone, A Privileged Scaffold in Drug Discovery: Developments in the
Synthesis and Bioactivity
Volume: 22
Issue: 7
Author(s): Anjitha Theres Benny, Sonia D. Arikkatt , Cijo George Vazhappilly, Sathananthan Kannadasan, Renjan Thomas, Manju Sreedharan Nair Leelabaiamma, Ethiraj Kannatt Radhakrishnan*Ponnusamy Shanmugam
Affiliation:
- Department of Chemistry, School of Advanced Sciences, VIT, Vellore 632014, India
Keywords:
Chromones, synthetic transformation, anti-cancer, antimicrobial, anti-diabetic, anti-viral.
Abstract: Chromones are the class of secondary metabolites that broadly occur in the plant kingdom
in a noticeable quantity. This rigid bicyclic system has been categorized “as privileged scaffolds in
compounds” in medicinal chemistry. Their wide biological responses have made them an important
moiety in a drug discovery program. This review provides updates on the various methods of synthesis
of chromones and biological applications in medicinal chemistry. Various synthetic strategies for
the construction of chromones include readily available phenols, salicylic acid and its derivatives,
ynones, chalcones, enaminones, and 2-hydroxyarylalkylketones as starting materials. Synthesis of
chromones by using metal, metal-free, nanomaterials and different other catalysts is herein included.
Details of diverse biological activities of chromone derviatives, such as anti-cancer, antimicrobial,
anti-viral, anti-inflammatory, antioxidant, as Monoamine Oxidase-B (MAO-B) inhibitors, anti-
Alzheimer’s agents, anti-diabetic agents, having antihistaminic potential, and acting as antiplatelet
agents, are discussed.