Title:Altered Biological Rhythm and Alzheimer's Disease: A Bidirectional Relationship
Volume: 18
Issue: 9
Author(s): Manli Wang, Hang Yu, Song Li, Yang Xiang and Weidong Le*
Affiliation:
- Department of Neurology, Sichuan Academy of Medical Sciences-Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu,China
Keywords:
Biological rhythm disruption, Alzheimer's disease, two-way interaction, biological rhythm, biological clock gene,
sleep disruption.
Abstract: Biological rhythms have become the research focus in recent years. Biological rhythm
disruption is a common symptom of Alzheimer's disease (AD) patients, which is usually considered
as the late consequence of AD. Recent studies have shown that biological rhythm disruption
even occurs before the onset of clinical symptoms of AD. The causal relationship between AD and
biological rhythm disruption is not clear. Delineating their relationship can help understand the disease
mechanisms and make the early diagnosis of AD possible. This review integrates the research
on the abnormal changes of the biological rhythm-related parameters in the clinical manifestations
of AD patients and the roles of the biological rhythm disorders in AD. We will discuss the links between
biological rhythms and AD, with the focus on the bidirectionality between biological
rhythms and AD processes. Collectively, these updated research findings may provide the basis for
further exploring the significance of rhythm in the diagnosis and treatment of AD.
