Title:Recent Progress in the Synthesis of Isoxazoles
Volume: 25
Issue: 24
Author(s): Dau Xuan Duc*Vo Cong Dung
Affiliation:
- Department of Chemistry, Vinh University, Vinh City, Nghe An Province,Vietnam
Keywords:
Cycloisomerization, α, β-acetylenic oximes, alkynyl oxime ethers, dipolar cycloaddition, nitrile oxide, chalcone oximes.
Abstract: Isoxazole derivatives are aromatic five-membered ring heterocyclic compounds
with one oxygen atom and one nitrogen atom at adjacent positions. These compounds
have a broad spectrum of applications in medicinal chemistry, such as antimicrobial, anticancer,
antitumor, antitubercular, analgesic, anti-inflammatory, antidepressant, and anticonvulsant
activities and some of them are well-known drugs for the treatment of various diseases in
the market. The use of this class of compounds in agriculture as herbicides, insecticides have
been widely reported. In organic materials, these compounds have been applied as semiconductors,
single-walled nanotubes, liquid crystals, chiral ligands, scaffolds for peptidomimetics,
dyes, and high-temperature lubricants. Isoxazole derivatives also play an important role in
organic synthesis because they can be converted into several important synthetic units such as
β-hydroxy ketones, γ -amino alcohols, α,β-unsaturated oximes, β -hydroxy nitriles, α-hydroxy-β-diketones, and β -
dicarbonyl compounds. Due to such a wide range of applicability, the synthesis of isoxazole derivatives has attracted
intensive research from chemists. This review will focus on considerable studies on the synthesis of isoxazoles which
date back from 2012.
