Title:Physical Work and Exercise Reduce the Risk of Cognitive Impairment in Older Adults: A Population-based Longitudinal Study
Volume: 18
Issue: 8
关键词:
身体活动、认知障碍、纵向研究、风险比、老年人、衰老。
摘要:
Background: The independent effect of physical work on the risk of cognitive impairment
in older Chinese older adults living in rural areas remains to be elucidated.
Objective: We aimed to determine whether physical work and physical exercise can reduce the risk of
cognitive impairment.
Methods: We collected data from 7,000 permanent residents without cognitive impairment (age ≥60
years) over a follow-up period of 2 years. We used the Chinese version of the Mini-Mental State Examination
(MMSE) to assess cognitive function. We performed multivariate Cox regression analyses
to calculate adjusted Hazard Ratios (HRs) and 95% Confidence Intervals (%95 CIs) as measures of the
association between physical work/exercise and cognitive impairment while controlling for potential
confounders.
Results: Over a median follow-up period of 1.93 years, 1,224 (17.5%) of 7,000 participants developed
cognitive impairment, with a total incidence of 97.69 per 1,000 person-years. After adjustment for
potential confounders, participating in physical work (HR: 0.51; 95% CI: 0.43-0.60) or physical exercise
(HR: 0.53; 95% CI: 0.44-0.65) was associated with a reduced risk of cognitive impairment. Stratified
analyses suggested additive and multiplicative interactions between physical work and exercise.
Agricultural work (HR: 0.46; 95% CI: 0.38-0.55), walking/tai chi (HR: 0.54; 95% CI: 0.44-0.67), and
brisk walking/yangko (HR: 0.57; 95% CI: 0.33-0.97) exerted significant protective effects against
cognitive impairment.
Conclusion: Both physical work and exercise can reduce the risk of cognitive impairment in older
adults. Reasonable types and appropriate intensities of physical activity are recommended to prevent or
delay the progression of cognitive impairment.
