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Review Article

维生素D在胃肠道疾病中的作用：炎症、胃癌和结直肠癌

卷 29, 期 22, 2022

发表于: 17 January, 2022

页: [3836 - 3856] 页: 21

弟呕挨: 10.2174/0929867328666211111163304

价格: $65

摘要

维生素D作为一种激素原在体内转化为活性形式，并与维生素D受体结合，发挥多种生物功能。最近的研究有力证实了补充维生素D与降低癌症风险和良好预后相关。胃肠道癌症是全球与癌症相关的死亡的主要原因。研究已经表明了维生素D在胃肠道癌发展中的关键作用。此外，维生素D还可以影响先天免疫力，起到抗炎和抗感染的作用。鉴于癌症与炎症之间的密切关系，我们在此总结了我们小组和其他研究人员对维生素D进行的流行病学和临床前的研究及其在炎症、胃癌和结直肠癌中作用的潜在机制。不同的研究证实了维生素D对癌症和炎症疾病的有益作用。在得出可靠结论并实现补充维生素D辅助治疗胃肠道炎症和癌症之前，研究还需要更多的对照和更大规模的临床试验。

关键词: 维生素D，新陈代谢，先天免疫力，抗菌肽，炎症，胃肠癌

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