Title:Central Nervous System Disorders Associated to Immune Checkpoint Inhibitors
Volume: 18
Issue: 2
Author(s): Felipe Fanine de Souza*, Julia Petry Trevisani, Letícia Caroline Breis, Luís Gustavo Marcelino Sizenando, Marco Antônio Machado Schlindwein, Paola Herreira Silva, Gustavo da Cunha Ribas and Marcus Vinicius Magno Gonçalves
Affiliation:
- University of the Region of Joinville, UNIVILLE, Joinville, SC-Brazil
Keywords:
Immune checkpoints inhibitors, encephalitis, paraneoplastic syndromes, immunomodulators, neurological diseases, monoclonal antibodies.
Abstract: New therapies and alternatives for the containment of tumor progression are being proposed
for the treatment of cancer. In this context, monoclonal therapies using Immune Checkpoint
Inhibitors (ICI) come as a therapeutic proposal. They are responsible for immunological control by
blocking PD-1, PD-L1 and CTLA-4 molecules. However, among the effects caused by therapy, the
use of medications is associated with neurological diseases reported as an adverse effect, affecting
the Central Nervous System (CNS) and causing a wide range of symptoms. In this regard, the present
bibliographic review presents the main CNS disorders associated with this therapy, in addition
to the incidence, symptoms and treatment of these diseases.
