Title:Resveratrol and Colorectal Cancer: A Molecular Approach to Clinical Researches
Volume: 21
Issue: 29
Author(s): Eisa Kaveh Vernousfaderani, Negin Akhtari, Sara Rezaei, Yasaman Rezaee, Saba Shiranirad, Melika Mashhadi, Ali Hashemi, Hamed Parsa Khankandi and Sahar Behzad*
Affiliation:
- Evidencebased Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj,Iran
Keywords:
Resveratrol, Colorectal cancer, Stilbenoid, Phenolic compound, Pharmacology, Pharmacokinetic, Clinical study.
Abstract: Phytochemicals are the most valuable and comprehensive structures, which may have a
broad range of protective benefits, from reducing inflammation and speeding healing to preventing
infection and fighting cancer. Resveratrol (RSV) is a natural phenolic compound from the oligomeric
stilbenoids group, which is usually found in daily human diet, such as grape, peanut, berries and
grains. It exhibits anti-inflammatory, neuroprotective, antioxidant, and cancer prevention and treatment
effects. RSV is thought to have an impressive outcome in colorectal cancer (CRC) treatment
through the vital molecules and cancer signaling pathways, including SIRT1, P53, P21, AMPK, ROS,
BMP7, COX-2, NO, caspases, Wnt, TNFs, NF-κB, EMT, and pentose phosphate pathway. Therefore,
this paper reviews the current researches on the pharmacological effects and pharmacokinetics of
resveratrol and its drug delivery system, as well as clinical studies involving CRC.
