Title:Application of Some Graphene Derivatives to Increase the Efficiency of
Stem Cell Therapy
Volume: 17
Issue: 3
Author(s): Tahereh Foroutan*
Affiliation:
- Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
Keywords:
Stem cell, graphene oxide, regenerative medicine, differentiation, mesenchymal stem cell, osteogenesis.
Abstract: Graphene and its derivatives have application potential in many areas such as environmental
technology, catalysis, biomedicine, and in particular, stem cell-based differentiation and regenerative
therapies. Mesenchymal stem cell transplantation has emerged as a potential therapy for
some diseases, such as acute kidney damage, liver failure and myocardial infarction. However, the
poor survival of transplanted stem cells in such applications has significantly limited their therapeutic
effectiveness. Graphene-based materials can improve the therapeutic efficacy of stem cells as
they prevent the death of implanted cells by attaching them prior to implantation and increasing
their paracrine secretion. In this review, we will highlight a number of recent studies that have investigated
the potential use of graphene or its derivatives in stem cell applications and the prevention
of transplanted stem cells from cell death, thereby improving their therapeutic efficacy.