Title:An Overview of C19MC Cluster Subgroup 3 and Cancer
Volume: 10
Issue: 3
Author(s): Ángela Y. García Fonseca, Janneth Gonzalez Santos and Andrés Felipe Aristizábal-Pachón*
Affiliation:
- Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C.,Colombia
Keywords:
MicroRNAs, microRNAs therapy, oncomirs, tumor suppressor, gene regulation, homology sequences.
Abstract: The primate-specific microRNA gene cluster on chromosome 19 (C19MC) is composed
of 56 mature microRNAs (miRNAs), which are divided into three subgroups according to the sequence
similarity. This cluster is principally expressed in the placenta but not in other tissues.
C19MC is involved in the regulation of proliferation, migration, and invasion of trophoblastic
cells, which are important for the development of the placenta. There is a growing number of
studies that have found an altered expression of some miRNAs of the C19MC cluster in cancer,
suggesting that these could play an important role in the development of this disease. Therefore, in
this work, we provided an overview of the C19MC cluster's role in cancer through a systematic review
of published articles. In particular, we focused on miRNAs of subgroup 3. These studies
suggest that miRNAs such as miR-512-3p, miR-512-5p, miR-516a-5p, miR-516b-5p, and
miR-498-5p could play a pivotal role in the development of therapies for cancer. Future studies are
necessary to elucidate the molecular processes and pathways regulated by subgroup 3 miRNAs.
