Title:Domperidone Withdrawal in a Nursing Female with Pre-existing Psychiatric
Illness: A Case Report
Volume: 17
Issue: 3
Author(s): Verinder Sharma*, Sapna Sharma and Minakshi Doobay
Affiliation:
- Department of Psychiatry, Western University, Ontario, ON, Canada
Keywords:
Domperidone, lactation, withdrawal-induced, depression, OCD, galactagogue.
Abstract:
Background: In this report, we describe a case of domperidone withdrawal in a woman
with a history of major depressive disorder and obsessive-compulsive disorder (OCD), who experienced
a recurrence of these disorders after stopping domperidone.
Case Presentation: The symptoms improved after the restarting of domperidone and disappeared
gradually as the drug was tapered and discontinued. Clinicians should consider domperidone withdrawal
a differential diagnosis in women with a history of depression or anxiety who present with
an acute onset of these symptoms following the abrupt discontinuation of domperidone.
Conclusion: A gradual taper off of the drug may be effective in minimizing withdrawal symptoms
and obviate the need for psychotropic drug use.