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Review Article

抗病毒化合物合成中的多组分反应

卷 29, 期 12, 2022

发表于: 11 January, 2022

页: [2013 - 2050] 页: 38

弟呕挨: 10.2174/0929867328666211007121837

价格: $65

摘要

背景：多组分反应是合成高度官能化的杂环和杂无环化合物的单罐工艺，通常具有生物活性。 目的：多组分反应被认为是具有高原子经济性的绿色过程。此外，与传统的合成方法相比，它们具有高效率和低废物产生等优点。 方法：在这些反应中，将两种或多种试剂在同一烧瓶中组合在一起，以产生含有原料几乎所有原子的产物。 结果：本综述论述了多组分反应在具有抗病毒活性的化合物合成中的应用。合成根据病毒靶标进行分类。 结论：多组分反应可以应用于药物发现和开发过程的所有阶段，使其在寻找对新兴（病毒）病原体有活性的新药剂方面非常有用。

关键词: 多组分反应，抗病毒活性，DNA / RNA病毒，passerini，ugi，strecker，hantzsch，biginelli。

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