Title:Promising Protective Effects of Chrysin in Cardiometabolic Diseases
Volume: 23
Issue: 5
Author(s): Marjan Talebi, Mohsen Talebi, Tahereh Farkhondeh, Jesus Simal-Gandara, Dalia M. Kopustinskiene, Jurga Bernatoniene, Ali Mohammad Pourbagher-Shahri and Saeed Samarghandian*
Affiliation:
- Noncommunicable
Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran
Keywords:
Chrysin, metabolic syndrome, diabetes mellitus, cardiovascular diseases, flavonoid, cardioprotective effects.
Abstract: Cardiometabolic diseases (CMD) have caused a great burden in terms of morbidity and
mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia,
obesity, and atherosclerosis. They have interlinked pathways, interacting and interconnecting
with each other. The natural flavonoid chrysin has been shown to possess a broad spectrum of
therapeutic activities for human health. Herein, we did an in-depth investigation of the novel mechanisms
of chrysin’s cardioprotection against cardiometabolic disorders. Studies have shown that
chrysin protects the cardiovascular system by enhancing the intrinsic antioxidative defense system.
This antioxidant property enhanced by chrysin protects against several risk factors of cardiometabolic
disorders, including atherosclerosis, vascular inflammation and dysfunction, platelet
aggregation, hypertension, dyslipidemia, cardiotoxicity, myocardial infarction, injury, and remodeling,
diabetes-induced injuries, and obesity. Chrysin also exhibited anti-inflammatory mechanisms
through inhibiting pro-inflammatory pathways, including NF-κB, MAPK, and PI3k/Akt. Furthermore,
chrysin modulated NO, RAS, AGE/RAGE, and PPARs pathways which contributed to the
risk factors of cardiometabolic disorders. Taken together, the mechanisms in which chrysin protects
against cardiometabolic disorder are more than merely antioxidation and anti-inflammation in
the cardiovascular system.
