Title:Synthetic Approach to Potential Anticancer Benzimidazole Derivatives: A
Review
Volume: 22
Issue: 9
Author(s): Rajnish Kumar*, Chanchal Singh, Avijit Mazumder, Salahuddin, Md. Mustaqeem Abdullah, Vivek Kumar and Pavan Prakash Giri
Affiliation:
- Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater
Noida, India
Keywords:
Anticancer, benzimidazole, derivatives, synthesis, amidine, bicyclic ring, cancer.
Abstract: Cancer is one of the deadliest diseases in many developed and developing countries. Continuous
efforts are required for designing better therapeutic agents for the treatment of cancer with
more efficacy, selectivity, and less toxicity. The fused heterocyclic ring system has been identified by
several researchers as a privileged structure that can be used as the basis for drug discovery in medicinal
chemistry. The hetero-aromatic bicyclic ring system acts as a pharmacophore in a wide range of
drugs with therapeutic potential. According to studies in the literature, various substituted benzimidazoles
have distinct pharmacological profiles with multi-targeting ability, making them an important
anchor for the production of novel therapeutic agents against complex cancers, including breast cancer,
skin cancer, and blood cancer. In this article, we have discussed various synthetic methods for the
synthesis of anti-cancer benzimidazoles and their derivatives in different solvent conditions, substrates,
and various catalysts, mainly those which are eco-friendly and economical. We also focused
on various derivatives those are under clinical trials containing benzimidazole moiety.