Title:Efficient Synthesis of Novel N-[4-Methyl-3-(4-(5-phenyl-1,3,4-oxadiazol-2-
yl)phenyl)thiazol-2(3H)-ylidene]benzamide Hybrid Ring System as
Potential Antibacterial Agents
Volume: 18
Issue: 2
Author(s): Hummera Rafique*, Aamer Saeed, Muhammad Naseem, Tauqeer Riaz, Fouzia Perveen, Amara Mumtaz, Aneela Maalik and Muhammad Sharif
Affiliation:
- Department of Chemistry, Univeristy of Gujrat, Gujrat-50700, Pakistan
Keywords:
Ethyl-4-aminobenzoate, thioureas, thiazolines, oxadiazoles, antibacterial activities, molecular docking, QSAR studies.
Abstract: Background: Heterocyclic compounds display versatile biological applications, so the
aim of this paper was to prepare biologically important heterocycles with enhanced bacterial resistance
and to evaluate for their various structural features that are responsible for their biological
properties.
Objective: The objective was to synthesize bacterial resistance compounds with enhanced antibacterial
properties.
Methods: Ester moiety containing thiazole ring was converted into its hydrazide derivatives. These
heterocyclic derivatives were cyclized into another ring oxadiazole; hence a hybrid ring system of
two biologically active rings was prepared.
Results: All the synthesized compounds were characterized by spectroscopic techniques and were
screened for their antibacterial potential; they possess significant antibacterial activities.
Conclusion: New hybrid heterocyclic ring systems were synthesized by cyclization of hydrazide
derivatives by adopting two step strategy in good yields. All the synthesized compounds were evaluated
for their antioxidant activities; they showed moderate to significant activities. QSAR and Molecular
docking studies were performed to determine the mode of interaction. Experimental and
computational data is in accordance with the determined antibacterial activities.