Recent Studies on Neglected Drug Design

Title:Recent Studies on Neglected Drug Design

Volume: 21 Issue: 21

Author(s): Natália Ferreira de Sousa, Luciana Scotti *, Gabriela Cristina Soares Rodrigues, Érika Paiva de Moura, Renata Priscila Barros Costa Barros, Zoe L. Sessions, Eugene N. Muratov and Marcus Tullius Scotti

Affiliation:

• Postgraduate Program of Natural and Synthetic Bioactive Products (PgPNSB), Health Sciences Center, Federal University of Paraiba, Joao Pessoa-PB,Brazil

Keywords: Neglected diseases, Drug discovery, Medicinal chemistry, Computer-aided drug design (CADD), Ligand-based drug design (LBDD), Structure-based drug design (SBDD), Organic synthesis.

Abstract:

Background: Neglected diseases require special attention when looking for new therapeutic alternatives, as these are diseases of extreme complexity and severity that affect populations belonging to lower social classes who lack access to basic rights, such as sanitation.

Introduction: Among the alternatives available for obtaining new drugs is Medicinal Chemistry, which is responsible for the discovery, identification, invention, and preparation of prototypes. In this perspective, the present work aims to make a bibliographic review on the recent studies of Medicinal Chemistry applied to neglected diseases.

Methods: A literature review was carried out by searching the “Web of Sciences” database, including recent articles published on the Neglected Drug Design.

Results: In general, it was noticed that the most studied neglected diseases corresponded to Chagas disease and leishmaniasis, with studies on organic synthesis, optimization of structures, and molecular hybrids being the most used strategies. It is also worth mentioning the growing number of computationally developed studies, providing speed and optimization of costs in the procurement process.

Conclusion: The CADD approach and organic synthesis studies, when applied in the area of Medicinal Chemistry, have proven to be important in the research and discovery of drugs for Neglected Diseases, both in terms of planning the experimental methodology used to obtain it and in the selection of compounds with higher activity potential.

Cite this article as:

de Sousa Ferreira Natália, Scotti Luciana *, Rodrigues Cristina Soares Gabriela, de Moura Paiva Érika , Costa Barros Priscila Barros Renata , Sessions L. Zoe , Muratov N. Eugene and Scotti Tullius Marcus, Recent Studies on Neglected Drug Design, Current Topics in Medicinal Chemistry 2021; 21 (21) . https://dx.doi.org/10.2174/1568026621666210920155939