Title:Natural Inhibitors against Potential Targets of Cyclooxygenase, Lipoxygenase
and Leukotrienes
Volume: 25
Issue: 14
Author(s): Rishita Dey, Sudatta Dey, Asmita Samadder, Anil Kumar Saxena*Sisir Nandi*
Affiliation:
- Global Institute of Pharmaceutical Education and Research (Affiliated to Uttarakhand Technical University),
Kashipur-244713, India
- Global Institute of Pharmaceutical Education and Research (Affiliated to Uttarakhand Technical University),
Kashipur-244713, India
Keywords:
Pain and inflammation mediators, COX, LOX, leukotrienes (LTs), natural inhibitors, alternative medicine.
Abstract:
Background: Cyclooxygenase (COX) and Lipoxygenase (LOX) enzymes catalyze the
production of pain mediators like Prostaglandins (PGs) and Leukotrienes (LTs), respectively from
arachidonic acid.
Introduction: The COX and LOX enzyme modulators are responsible for the major PGs and LTs
mediated complications like asthma, osteoarthritis, rheumatoid arthritis, cancer, Alzheimer’s disease,
neuropathy and Cardiovascular Syndromes (CVS). Many synthetic Nonsteroidal Anti-
Inflammatory Drugs (NSAIDs) used in the treatment have serious side effects like nausea, vomiting,
hyperacidity, gastrointestinal ulcers, CVS, etc.
Methods: The natural inhibitors of pain mediators have great acceptance worldwide due to fewer
side effects on long-term uses. The present review is an extensive study of the advantages of plantbased
vs synthetic inhibitors.
Results: These natural COX and LOX inhibitors control inflammatory response without causing
side-effect-related complicacy.
Conclusion: Therefore, the natural COX and LOX inhibitors may be used as alternative medicines
for the management of pain and inflammation due to their less toxicity and resistivity.
