Title:Insight into the Isolation, Synthesis, and Structure-Activity Relationship of Piperine Derivatives for the Development of New Compounds: Recent Updates
Volume: 21
Issue: 30
Author(s): Afreen, Salahuddin*, Avijit Mazumder, Sagar Joshi, Rajnish Kumar, Mohammad Shahar Yar and Mohamed Jawed Ahsan
Affiliation:
- Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), 19, Knowledge Park II, Greater Noida, U.P. – 201306,India
Keywords:
Piperine derivatives, Isolation of piperine, Pharmacological activity, SAR of piperine, Anti-cancer activity, Piper
nigrum.
Abstract: Currently, black pepper commands the leading position among all the spices as a spice of
great commercial importance in all the world trade and finds its way into the dietary habits of millions
of people worldwide. Black pepper is biologically known as Piper nigrum and contains piperine as
the main active chemical constituent. This paper highlights various general methods for extracting
piperine from the crude drug such as maceration extraction, hydrotropic extraction, accelerated solvent
extraction, thin-layer chromatography, and extraction with ethanol & dichloromethane Ionic
fluid-based ultrasonic-assisted extraction, etc. In this review, piperine and its analogs exhibit numerous
pharmacological activities and synthetic schemes of insecticidal activity, anti-cancer activity,
anti-inflammatory activity, anti-diabetic activity, anti-hyperlipidemic activity, antifungal activity,
narcotic activity, etc. and its structure-activity relationship. The biochemistry of piperine has also
been summarized in the presented article. This very exhaustive review details the complete information
about piperine, its derivatives, and further processing. Furthermore, the current study summarises
recent research that has linked piperine to its use as a treatment for a variety of ailments.