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Review Article

二肽基肽酶家族：结构、功能与异种生物代谢的研究进展

卷 29, 期 12, 2022

发表于: 11 January, 2022

页: [2167 - 2188] 页: 22

弟呕挨: 10.2174/0929867328666210915103431

价格: $65

摘要

脯氨酰特异性肽酶或蛋白酶，包括二肽基肽酶 2、4、6、8、9、10、成纤维细胞活化蛋白、脯氨酸内肽酶和脯氨酰羧肽酶，属于二肽基肽酶家族。在人体生理学和解剖学中，它们具有同源氨基酸序列和结构的相似性;然而，它们具有不同的功能并扮演不同的角色。其中一些在含有内源性肽，含有异种生物和外源性肽的药物的代谢中也起着重要作用。这些肽酶在人体健康和生物活性肽代谢中的主要功能在开发有效抑制剂以控制内源性生物活性肽代谢方面具有重要意义。本文综述了组织结构特征、组织分布、内源性底物和生物学功能。此外，还说明了二肽基肽酶家族的异种生物代谢。本综述中总结的所有证据和信息对于研究人员扩展对这些家族蛋白质的理解非常有用，并为生理学和病理学研究提供建议和帮助。

关键词: 二肽基肽酶家族，代谢，检测方法，抑制剂，脯氨酰羧肽酶，FAP。

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