Title:An Updated Review for the Diabetic Wound Healing Systems
Volume: 23
Issue: 4
Author(s): Mehmet E. Okur, Ece Ö. Bülbül, Gökçe Mutlu, Kalliopi Eleftherıadou, Ioannis D. Karantas, Neslihan Ü. Okur*Panoraia I. Siafaka*
Affiliation:
- Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Health Sciences, Istanbul, Turkey
- KES College, Nicosia, Cyprus
Keywords:
Diabetic wounds, Antimicrobials, Growth factors, Scaffolds, Natural compounds, Wound healing.
Abstract: Background & Objective: Diabetes is a global health problem that has resulted in millions
of deaths; one of the most common diabetes complications is that wounds of diabetic patients
tend to heal more slowly or may not heal at all, resulting in undesirable outcomes. Diabetic
wounds, if become chronic and infected, could provoke lower extremities amputation, sepsis, and
even death. Hence, early detection, careful examination, debridement, cleaning, and prevention or
controlling the infection of diabetic wounds are important factors for the successful outcome of the
case. Over the years, various promising wound dressings incorporating antimicrobial molecules,
growth factors, and wound healing agents have been developed, targeting diabetic wounds.
Nonetheless, the choice of dressing is mainly based on the experience of each clinician.
Summary: This review summarizes the main points of diabetes complications, diabetic wounds,
and infections. Further, an overview of the current drug delivery systems for topical wound delivery
of various active ingredients has been performed. This update could be helpful for scientists
and especially clinicians who desire to plan and work with new strategies for the healing of diabetic
wounds.
