Title:Herbal Plethora for Management of Neurodegenerative Disorders:
An Invigorating Outlook
Volume: 18
Issue: 1
Author(s): Garima Yadav, Tarique Mahmood Ansari*, Arshiya Shamim, Supriya Roy, Mohd Masih Uzzaman Khan, Farogh Ahsan, Mohammad Shariq, Saba Parveen and Rufaida Wasim
Affiliation:
- Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh 226026, India
Keywords:
Antioxidant, Alzheimer’s, herbal drugs, neurodegeneration, oxidative stress, Parkinson’s.
Abstract: Abstract: Oxidative stress, proteasomal impairment, mitochondrial dysfunction, and accumulation
of abnormal protein aggregates have shovelled a major section of the senior population
towards neurodegenerative disorders. Although age, genetic and environmental factors are
thought to play a significant role, drug abuse is considered to be a potent trigger in Parkinsonism
among the young generation. The present study is a critical examination of herbal resources
for attenuation of neurodegeneration.
The following electronic databases have been used to search for literature: MEDLINE, Scopus,
PubMed, and EMBAS.
Paying heed to the prevalence of neurodegenerative disorders such as Alzheimer’s and Parkinson’s,
the current review encompasses the pathogenesis of neurodegeneration at the cellular
level and possible prospects to overcome the challenge sailing through the ocean of herbal
boon. The United States’s Alzheimer’s Association states that deaths attributable to heart disease
in the country fell by 11% between 2000 and 2015, while deaths from neurodegenerative
diseases increased by a staggering 123% making it, the world’s sixth-leading cause of death.
The irreversible pathological damage amounts to cognitive loss, dementia, Amyotrophic lateral
sclerosis (ALS), Parkinson’s disease (PD) Alzheimer’s disease (AD).
Various herbal drugs like Brahmi, Shankhpushpi, and Amla are reported to be rich in phytoconstituents
like flavonoids, glycosides, alkaloids, fatty acids, sterols, tannins, saponins, and
terpenes that have remarkable antioxidant potential and could be explored for the same to prevent
neuronal necrosis.
It is also believed that herbal medicines are more effective and less toxic than synthetic drugs.