Title:The Effect of Uphill and Downhill Eerobic Exercises on Serum Apolipoprotein
A1 and Apolipoprotein B Levels and their Ratio in Patients with
Chronic Obstructive Pulmonary Disease
Volume: 17
Issue: 3
Author(s): Rostam Yazdani, Hamid Marefati, Armita Shahesmaeili, Alireza Bagheri, Ahmad Alinaghi Langari*, Samira Nakhaei*, Mahmoud Amiri and Halimeh Kameshki
Affiliation:
- Student of Medicine, Student Research Committee, School of Medicine, Kerman University of Medical
Sciences, Kerman, Iran
- Department of Internal Medicine, Kerman University of Medical Sciences, Kerman, Iran
Keywords:
Apolipoprotein A1, apolipoprotein B, chronic obstructive pulmonary disease, downhill, exercise, uphill.
Abstract: Background: Chronic obstructive pulmonary disease (COPD) is a major health issue
worldwide.
Introduction: This study aimed to evaluate the effect of aerobic exercises at steep surfaces on Apo
A1 and Apo B serum levels and their ratio in COPD patients.
Methods: This interventional study was undertaken on 16 COPD patients. The sample was selected
by using the random sampling method. Patients were randomly divided into 2 groups of 8 members:
uphill and downhill. Spirometry was conducted prior to the exercises and pulmonary volumes
were measured. Aerobic exercises (stationary bicycle and treadmill) were started 3 times a week
for 8 weeks. The duration of exercises in each session was determined based on the patients’ ability
(30-40 min). In the first and second group, exercises were performed on sloped surfaces that
were downwards and upwards at a 10-degree angle, respectively. Blood samples were taken from
the patients before and after the 8 weeks. Apo A1 and Apo B serum levels and Apo A1 to Apo B ratio
were measured. Data were analyzed by SPSS software. P<0.05 was considered statistically significant.
Results: ApoA1/Apo B ratio in the uphill group before and after the intervention was 1.43±0.21
and 1.53±0.24 mg/dL, respectively, with P-value=0.36. In the downhill group, this value was
1.27±0.17 and 1.30±0.18, respectively, with a P-value=0.032.
Conclusion: In light of the results of the present study, incorporating downhill exercises in COPD
patients' rehabilitation program can help improve pulmonary function and prevent atherosclerotic
events.
