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Review Article

载紫杉烷的脂基纳米载体在乳腺癌治疗中的应用:前景与挑战

卷 23, 期 6, 2022

发表于: 24 August, 2021

页: [544 - 558] 页: 15

弟呕挨: 10.2174/1389450122666210824144304

价格: $65

摘要

乳腺癌是全世界妇女死亡的主要原因。紫杉烷（最有利的一类二萜药物）在治疗早期和转移性乳腺癌中显示出了动态的潜力。然而，生物利用度差、组织渗透性低、水溶性差、剂量依赖性副作用等挑战限制了这些药物的临床应用。因此，为了克服这些挑战，人们正在探索各种基于纳米技术的药物输送系统，用于在乳腺癌治疗中输送紫杉烷。其中一个很有潜力的纳米载体类别是脂基纳米载体，它利用了各种天然和合成来源的脂类的优点。众所周知，脂质摄取在乳腺癌细胞增殖和肿瘤发生中起着重要作用。基于脂质的纳米载体可能是一个绝佳选择，可以将溶解性和渗透性较差的紫杉烷纳米封装起来，用于乳腺癌的治疗。这些系统在提高生物利用度、空间和时间紫杉烷递送、提高疗效、降低给药频率，甚至轻度抑制 P-gp 流出机制方面具有巨大的前景。除了这些前景之外，这些载体还不能为最终的使用者带来好处。本综述不仅将讨论这些系统的优点、进展和前景，而且还将思考这些载体在进入临床为乳腺癌患者造福方面所面临的各种挑战。

关键词: 生物利用度，缓释，新型药物传递系统，药物释放细胞毒性，脂基纳米载体，乳腺癌细胞。

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