Title:Endemic and Indigenous Plants from Mascarene Islands with Antiviral
Propensities
Volume: 23
Issue: 1
关键词:
地方性,本土,药用植物,睫毛膏,岛屿,抗病毒药。
摘要: Background: Antiviral resistance and inefficiency of available antiviral drugs to effectively
treat viral infections have prompted many researchers worldwide to explore medicinal plants
and their isolated compounds as alternative antivirals. The rich flora from the Mascarene Islands
has also been thoroughly studied for their wide therapeutic activities, including their antiviral properties.
Objective: The aim of this review is to highlight the antiviral propensities of Mascarene endemic
and indigenous medicinal plants.
Methodology: A review of the literature was conducted via major databases and other primary
sources of information. The inhibitory concentration/effective dose causing 50% viral inhibition
(IC50/ED50), cytotoxic concentration causing 50% reduction in cell viability (CC50), and selectivity
index (SI) were reported, and mechanisms of antiviral action were also discussed.
Results: Stillingia lineata was the most effective against chikungunya virus (SI: 10.9), and among
its isolated compounds, 12-O-acetylphorbol-13(2″-methyl)- butyrate and 12-deoxyphorbol-
13(2″-methyl)butyrate were the most potent and selective inhibitors of chikungunya virus replication
(SI: 41 and >240, respectively). 12-O-acetylphorbol-13(2″-methyl)- butyrate, 12β-O-[nona-
2Z,4E,6E-trienoyl]-4α-deoxyphorbol-13-butyrate, 12-deoxyphorbol-13(2″-methyl)butyrate, and
12-deoxyphorbol-13-[8′-oxohexadeca-2E,4E,6E-trienoate showed strong selective antiviral effect
on human immunodeficiency virus-I (SI: 36-899) and II (SI: 33-2056). Obetia ficifolia and Erythroxylon
laurifolium were most active against the herpes virus (SI: 18.5 and 16, respectively).
Labourdonnaisia glauca showed potent anti-poliovirus activity (SI: 40), while Badula insularis,
Labourdonnaisia glauca and Myonima violacea were active against rhinovirus (SI: 1.3-2.5). Both
anti-zika and anti-dengue virus activities were reported for Aphloia theiformis, Doratoxylon apetalum,
Phyllanthus phillyreifolius and Psiloxylon mauritianum.
Conclusion: Promising spectrum of antiviral properties notably against zika, dengue, chikungunya,
polio-, rhino-, herpes, and human immunodeficiency viruses were presented by the Mascarene
plants suggesting them as viable candidates for the potential development of effective natural antiviral
drugs.