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Review Article

间充质干细胞和癌症干细胞：用于治疗干预的肿瘤-间充质干细胞相互作用概述

卷 23, 期 1, 2022

发表于: 24 August, 2021

页: [60 - 71] 页: 12

弟呕挨: 10.2174/1389450122666210824142247

价格: $65

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摘要

肿瘤由导致肿瘤异质性的不同类型的癌细胞组成。在这些细胞中，癌症干细胞 (CSC) 在癌症的发生和发展中具有重要作用。与其他干细胞一样，CSC 具有分化和自我更新的能力。特定的 CSC 群由分化为中胚层特异性细胞的间充质干细胞 (MSC) 构成。 MSCs 对肿瘤细胞增殖和发育的促进或抗肿瘤发生潜力已被报道为相互矛盾的结果。此外，肿瘤进展由相应的肿瘤细胞（如肿瘤微环境）指定。肿瘤微环境由相互细胞类型的网络组成，例如内皮细胞、免疫细胞、间充质干细胞和成纤维细胞以及生长因子、趋化因子和细胞因子。在这篇综述中，将讨论与肿瘤微环境和相关细胞群、MSCs 归巢到肿瘤部位以及 MSCs 与肿瘤细胞的相互作用相关的最新发现。

关键词: 间充质干细胞、癌症干细胞、肿瘤微环境、肿瘤细胞、间充质干细胞归巢、再生医学、治疗干预。

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