Title:Mesenchymal Stem Cells and Cancer Stem Cells: An Overview of Tumor-
Mesenchymal Stem Cell Interaction for Therapeutic Interventions
Volume: 23
Issue: 1
Author(s): Soheila Montazersaheb, Ezzatollah Fathi, Ayoub Mamandi, Raheleh Farahzadi*Hamid Reza Heidari
Affiliation:
- Stem Cell Research Center, Tabriz University of Medical Sciences,
Tabriz, Iran
- Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Keywords:
Mesenchymal stem cells, cancer stem cells, tumor microenvironment, tumor cells, homing of mesenchymal stem cells, regenerative medicine, therapeutic interventions.
Abstract: Abstract: Tumors are made up of different types of cancer cells that contribute to tumor heterogeneity.
Among these cells, cancer stem cells (CSCs) have a significant role in the onset of cancer
and development. Like other stem cells, CSCs are characterized by the capacity for differentiation
and self-renewal. A specific population of CSCs is constituted by mesenchymal stem cells (MSCs)
that differentiate into mesoderm-specific cells. The pro-or anti-tumorigenic potential of MSCs on
the proliferation and development of tumor cells has been reported as contradictory results. Also,
tumor progression is specified by the corresponding tumor cells like the tumor microenvironment.
The tumor microenvironment consists of a network of reciprocal cell types such as endothelial
cells, immune cells, MSCs, and fibroblasts as well as growth factors, chemokines, and cytokines.
In this review, recent findings related to the tumor microenvironment and associated cell populations,
homing of MSCs to tumor sites, and interaction of MSCs with tumor cells will be discussed.