Title:A Comprehensive Review on Chrysin: Emphasis on Molecular Targets, Pharmacological Actions and Bio-pharmaceutical Aspects
Volume: 23
Issue: 4
关键词:
白杨素，化学预防，抗癌，保护作用，抗抑郁，抗糖尿病，抗病毒，药代动力学
摘要: Chrysin (a flavonoid) has shown various promising pharmacological activities viz. anticancer,
anti-diabetic, immune-modulation, antidepressant, and anti-asthmatic. Additionally, it exhibited
potential protective effects against various toxins on different organs like the liver, brain,
kidney, and heart. A multitude of studies have been conducted to explore the possible targets for its
possible mechanism of action. However, its therapeutic applications have been limited due to its
poor oral bioavailability. The major reason for its poor bioavailability is its extensive first-pass
metabolism. A critical review of the pharmacological properties of chrysin and its associated molecular
targets has not been discussed as yet comprehensively. Therefore, the emphasis of the present
work is to provide an in-depth understanding of molecular targets accountable for the pharmacological
actions of chrysin. Moreover, a schematic diagram was made for the first time to represent the
comprehensive pharmacokinetic properties of chrysin, which helps to understand the biopharmaceutical
aspect for its successful delivery. An in-depth understanding of the biopharmaceutical
properties of chrysin will help in adopting a suitable formulation approach to overcome poor oral
bioavailability. Additionally, it facilitates to study the possible pharmacokinetic interactions of
chrysin with other drugs. Hence, we found that chrysin is a miraculous natural agent with myriad
therapeutic properties, and its benefit can be exploited with an in-depth understanding of molecular
targets, pharmacological actions, and biopharmaceutical attributes.
