Title:Genomics and Pharmacogenomics of Age-related Hearing Loss
Volume: 18
Issue: 2
Author(s): Joaquin Guerra*, Vinogran Naidoo and Ramon Cacabelos
Affiliation:
- EuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, Bergondo
15165 Corunna, Spain
Keywords:
Presbycusis, genomics, pharmacogenomics, age-related hearing loss, APOE, NAT2, MTHFR.
Abstract: Abstract: Age-related hearing loss (ARHL) or presbycusis shares common features with conditions
related to senescence and neurodegeneration. In this review, we explore the linking of genes involved
in such processes with presbycusis, that has been proven to share important relationships with genes
involved in dementia (APOE and MTHFR), ototoxicity (the GST group), and pharmacogenetics
(NAT2). In this regard, we propose the construction of pharmacogenetics for the presbycusis database
that could help better control side effects in this particularly vulnerable population susceptible to neurodegenerative
disorders. Moreover, preliminary epigenetics studies have recently identified links in
human genes involved in ARHL, which could serve as biomarkers or as therapeutic targets.