Title:The Hepatoprotective Role of Warburgia salutaris and Iso-Mukaadial Acetate
on Carbon Tetrachloride Intoxicated Rats Model
Volume: 18
Issue: 4
Author(s): Gideon Ayeni, Mthokozisi Blessing Cedric Simelane, Md. Shahidul Islam and Ofentse Jacob Pooe*
Affiliation:
- Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa
Keywords:
Hepatoprotection, warburgia salutaris, iso-mukaadial acetate, medicinal plants, antioxidants, complementary alternative medicine, hepatoprotective, liver protection.
Abstract:
Background: Medicinal plants, together with their isolated bioactive compounds, are
known for their antioxidant properties, which constitute therapeutic agents that are routinely employed
in the treatment of liver diseases.
Aims of the Study: The current study sought to explore the protective role of Warburgia salutaris
and its isolated compound, iso-mukaadial acetate, against carbon tetrachloride (CCl4)-induced hepatic
injury.
Methods: Thirty-five male Sprague Dawley rats were divided into seven groups of five animals
each and injected with CCl4 to induce hepatic injury.
Results: Treatment with the crude extract of W. salutaris and iso-mukaadial acetate significantly reduced
the levels of alkaline phosphatase, alanine and aspartate amino transaminases, and total
bilirubin and malondialdehyde in a dose-dependent manner compared to untreated groups. Liver
histology revealed a reduction in hepatic necrosis and inflammation.
Conclusion: The current investigation has demonstrated that W. salutaris extract and iso-mukaadial
acetate could mitigate the acute liver injury inflicted by a hepatotoxic inducer in rats.