Title:Synthesis and Biological Activity of 2,7-Naphthyridine Derivatives: An Overview
Volume: 25
Issue: 22
Author(s): Anna Wójcicka*
Affiliation:
- Department of Pharmaceutical Technology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Borowska 211A, 50-556 Wroclaw,Poland
Keywords:
2, 7-Naphthyridines, pyridopyridines, benzo[c][2, 7]naphthyridines, synthesis, copyrine derivatives, biological activity.
Abstract: 2,7-Naphthyridine is one of the six structural isomers of pyridopyridine. Biological
investigations have shown that these compounds have a broad spectrum of activity. They have
been found to have antitumor, antimicrobial, analgesic and anticonvulsant effects. The broad
spectrum of biological activity of 2,7-naphthyridine derivatives is the main reason for the
preparation of new compounds containing this scaffold. This review aims to present various
methods of obtaining 2,7-naphthyridine analogs. Compounds containing a 2,7-naphthyridine
moiety can be synthesized from a variety of substrates and may be classified into four main
categories: those derived from acyclic compounds, from quinoline derivatives, from pyridine
derivatives, and from other compounds. Most of them were obtained by the cyclocondensation
or intramolecular cyclization of pyridine derivatives. Cyclocondensations of non-cyclic substrates
also produced 2,7-naphthyridine derivatives. Tricyclic benzo[2,7]naphthyridines were prepared from quinolines.
The 2,7-naphthyridine scaffold has also been synthesized by the rearrangement of pyrrolo[3,4-c]pyridines,
pyrano[3,4-c]pyridines or thiopyrano[3,4-c]pyridines.