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Review Article

蝰蛇科毒液：有关其抗菌和抗肿瘤潜力的观点

卷 23, 期 2, 2022

发表于: 11 August, 2021

页: [126 - 144] 页: 19

弟呕挨: 10.2174/1389450122666210811164517

价格: $65

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摘要

多重耐药细菌的出现和癌症治疗的局限性代表了现代医学的两个重要挑战。已经探索了生物化合物，特别关注毒液。尽管它们可能是致命的或对人类造成相当大的伤害，但毒液也是一种富含具有高治疗潜力的成分的来源。毒蛇科是最具代表性的毒蛇科之一，多项研究强调了毒蛇毒素的抗菌和抗肿瘤潜力。根据文献，这些活性主要与五个蛋白质家族有关——svLAAO、解聚素、PLA2、SVMPs 和 C 型凝集素——它们通过不同的机制发挥作用，从而抑制细菌的生长，以及细胞毒作用和转移过程的抑制。在这篇综述中，我们概述了属于蝰蛇科的物种产生的毒液毒素，探索它们在毒液中的作用及其药理特性，以展示其抗菌和抗肿瘤的潜力。

关键词: 蝮蛇毒、毒素、多重耐药菌、抗癌、抗菌、抗肿瘤

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