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Abstract
The emergence of multi-drug resistant bacteria and limitations on cancer treatment represent two important challenges in modern medicine. Biological compounds have been explored with a particular focus on venoms. Although they can be lethal or cause considerable damage to humans, venom is also a source rich in components with high therapeutic potential.
Viperidae family is one of the most emblematic venomous snake families and several studies highlighted the antibacterial and antitumor potential of viper toxins. According to the literature, these activities are mainly associated to five protein families - svLAAO, Disintegrins, PLA2, SVMPs and C-type lectins- that act through different mechanisms leading to the inhibition of the growth of bacteria, as well as, cytotoxic effects and inhibition of metastasis process. In this review, we provide an overview of the venom toxins produced by species belonging to the Viperidae family, exploring their roles during the envenoming and their pharmacological properties, in order to demonstrate its antibacterial and antitumor potential.
Keywords: Viperidae venoms, toxins, multi-drug resistant bacteria, cancer, antibacterial, antitumor.
[http://dx.doi.org/10.1038/nrmicro3380] [PMID: 25435309]
[http://dx.doi.org/10.7759/cureus.1403] [PMID: 28852600]
[http://dx.doi.org/10.1016/j.bcp.2016.12.005] [PMID: 27956111]
[http://dx.doi.org/10.1056/NEJMp1215093] [PMID: 23343059]
[http://dx.doi.org/10.1016/j.ijantimicag.2018.11.010] [PMID: 30472287]
[http://dx.doi.org/10.1128/MMBR.00016-10] [PMID: 20805405]
[http://dx.doi.org/10.1093/jac/dkp256] [PMID: 19675017]
[http://dx.doi.org/10.1016/j.tim.2011.04.005] [PMID: 21664819]
[http://dx.doi.org/10.1038/nrmicro2200] [PMID: 19680247]
[http://dx.doi.org/10.1016/j.mib.2006.08.011] [PMID: 16942899]
[http://dx.doi.org/10.1016/j.ijantimicag.2018.02.020] [PMID: 29501819]
[http://dx.doi.org/10.1086/420937] [PMID: 15127341]
[http://dx.doi.org/10.3389/fphar.2018.00203] [PMID: 29563876]
[http://dx.doi.org/10.1016/j.molmed.2007.04.004] [PMID: 17493872]
[http://dx.doi.org/10.3389/fmicb.2010.00134] [PMID: 21687759]
[http://dx.doi.org/10.1016/S0092-8674(00)81683-9] [PMID: 10647931]
[http://dx.doi.org/10.1016/j.cpha.2018.08.011]
[http://dx.doi.org/10.3322/caac.21565] [PMID: 31184787]
[http://dx.doi.org/10.1016/j.micpath.2018.09.003] [PMID: 30195644]
[http://dx.doi.org/10.1016/j.biotechadv.2018.08.001] [PMID: 30077715]
[http://dx.doi.org/10.1016/j.ejphar.2020.173100] [PMID: 32320704]
[http://dx.doi.org/10.1016/j.ejphar.2020.173817] [PMID: 33345849]
[http://dx.doi.org/10.1016/j.tranon.2019.09.011] [PMID: 31874375]
[http://dx.doi.org/10.1016/j.ijrobp.2020.07.1690]
[http://dx.doi.org/10.1053/j.seminoncol.2010.09.001] [PMID: 21074063]
[http://dx.doi.org/10.1126/science.271.5256.1734] [PMID: 8596936]
[http://dx.doi.org/10.1073/pnas.192461099] [PMID: 12218188]
[http://dx.doi.org/10.1093/intimm/dxh194] [PMID: 15611321]
[http://dx.doi.org/10.1016/j.cell.2017.07.024] [PMID: 28803728]
[http://dx.doi.org/10.1038/nbt.4017] [PMID: 29319699]
[http://dx.doi.org/10.1007/s00109-020-01944-5] [PMID: 32620999]
[http://dx.doi.org/10.1017/S0006323197005045] [PMID: 9336100]
[http://dx.doi.org/10.1016/j.phytochem.2007.04.032] [PMID: 17574638]
[http://dx.doi.org/10.1038/415389a] [PMID: 11807545]
[http://dx.doi.org/10.1016/j.toxicon.2018.05.004] [PMID: 29763628]
[http://dx.doi.org/10.1016/j.febslet.2009.03.029] [PMID: 19303875]
[http://dx.doi.org/10.1016/j.jpra.2020.11.004] [PMID: 33299920]
[http://dx.doi.org/10.1016/j.mjafi.2020.07.013]
[http://dx.doi.org/10.1016/S0140-6736(18)31224-8] [PMID: 30017551]
[http://dx.doi.org/10.1038/nrdp.2017.63] [PMID: 28905944]
[http://dx.doi.org/10.1016/j.biocel.2018.09.011] [PMID: 30261311]
[http://dx.doi.org/10.1002/jms.1242] [PMID: 17621391]
[http://dx.doi.org/10.1016/S0041-0101(98)00156-1] [PMID: 9792180]
[http://dx.doi.org/10.1007/s00018-006-6315-0] [PMID: 17103111]
[http://dx.doi.org/10.1016/j.toxicon.2011.03.017] [PMID: 21447352]
[http://dx.doi.org/10.1016/j.toxicon.2011.07.013] [PMID: 21835190]
[http://dx.doi.org/10.1152/ajplegacy.1949.156.2.261]
[PMID: 15688321]
[http://dx.doi.org/10.1016/j.biocon.2016.05.004]
[http://dx.doi.org/10.1016/j.ympev.2008.08.019] [PMID: 18804544]
[http://dx.doi.org/10.1016/S0041-0101(98)00126-3] [PMID: 9839663]
[http://dx.doi.org/10.1371/journal.pone.0001194] [PMID: 18030329]
[http://dx.doi.org/10.1016/j.toxicon.2008.11.001] [PMID: 19041663]
[http://dx.doi.org/10.1016/j.npep.2020.102081] [PMID: 32839009]
[http://dx.doi.org/10.1016/j.toxicon.2003.12.001] [PMID: 15033323]
[http://dx.doi.org/10.1111/jdv.16722] [PMID: 32530549]
[http://dx.doi.org/10.1016/j.cbpc.2019.02.013] [PMID: 30825636]
[http://dx.doi.org/10.1016/j.jprot.2020.103707] [PMID: 32087377]
[http://dx.doi.org/10.1016/j.jprot.2020.103758] [PMID: 32247171]
[http://dx.doi.org/10.1111/jbi.13861]
[http://dx.doi.org/10.1016/j.jprot.2012.02.021] [PMID: 22387316]
[http://dx.doi.org/10.1098/rspb.2009.0048]
[http://dx.doi.org/10.1016/j.toxicon.2005.02.020] [PMID: 15922778]
[http://dx.doi.org/10.1016/j.toxicon.2012.09.003] [PMID: 23010164]
[http://dx.doi.org/10.1016/j.jprot.2014.10.002] [PMID: 25452133]
[http://dx.doi.org/10.3390/molecules21101398] [PMID: 27775574]
[http://dx.doi.org/10.1016/j.toxicon.2016.11.001] [PMID: 27816537]
[http://dx.doi.org/10.1016/j.toxicon.2012.11.010] [PMID: 23178323]
[http://dx.doi.org/10.1016/j.toxicon.2005.02.030] [PMID: 15922768]
[http://dx.doi.org/10.1016/j.toxicon.2005.02.012] [PMID: 15922769]
[http://dx.doi.org/10.1111/j.1742-4658.2008.06466.x] [PMID: 18479462]
[http://dx.doi.org/10.3390/toxins8040093] [PMID: 27023608]
[http://dx.doi.org/10.1016/j.toxicon.2012.09.004] [PMID: 23000249]
[http://dx.doi.org/10.1016/j.toxicon.2018.03.005] [PMID: 29567103]
[http://dx.doi.org/10.1016/j.toxicon.2005.02.026] [PMID: 15922773]
[http://dx.doi.org/10.3892/ijmm.2014.1864] [PMID: 25069477]
[http://dx.doi.org/10.1016/j.toxicon.2006.12.003] [PMID: 17250863]
[http://dx.doi.org/10.1016/j.toxicon.2012.05.001] [PMID: 22579637]
[http://dx.doi.org/10.1016/j.toxicon.2018.06.064] [PMID: 29898379]
[http://dx.doi.org/10.1016/j.ijbiomac.2017.05.025] [PMID: 28495622]
[http://dx.doi.org/10.1016/j.jmb.2006.09.032] [PMID: 17046020]
[http://dx.doi.org/10.1016/S0041-0101(02)00102-2] [PMID: 12175601]
[http://dx.doi.org/10.1016/j.bmc.2006.06.025] [PMID: 16809041]
[http://dx.doi.org/10.1016/j.toxicon.2003.11.002] [PMID: 15019485]
[http://dx.doi.org/10.1016/j.toxicon.2011.01.006] [PMID: 21277886]
[http://dx.doi.org/10.1016/S1388-1981(00)00110-4] [PMID: 11080677]
[http://dx.doi.org/10.1016/S0041-0101(99)00104-X] [PMID: 10519645]
[http://dx.doi.org/10.1016/S1388-1981(00)00105-0] [PMID: 11080672]
[http://dx.doi.org/10.1016/j.toxicon.2005.02.024] [PMID: 15922775]
[http://dx.doi.org/10.1016/j.rmu.2017.02.004]
[http://dx.doi.org/10.1016/j.toxicon.2012.09.005] [PMID: 23010163]
[http://dx.doi.org/10.2174/1381612053381765] [PMID: 15777236]
[http://dx.doi.org/10.2174/1389203716666150515125002] [PMID: 26031306]
[http://dx.doi.org/10.1016/j.toxicon.2014.11.228] [PMID: 25450798]
[http://dx.doi.org/10.1016/j.toxicon.2018.11.294] [PMID: 30472110]
[http://dx.doi.org/10.1016/j.toxicon.2010.03.011] [PMID: 20350564]
[http://dx.doi.org/10.1016/j.toxicon.2012.03.001] [PMID: 22781131]
[http://dx.doi.org/10.1016/j.toxicon.2005.02.021] [PMID: 15922777]
[http://dx.doi.org/10.1111/j.1538-7836.2005.01358.x] [PMID: 16102046]
[http://dx.doi.org/10.1016/j.ijbiomac.2017.04.018] [PMID: 28400185]
[http://dx.doi.org/10.1016/j.toxicon.2010.12.001] [PMID: 21147145]
[http://dx.doi.org/10.1016/j.toxicon.2010.10.014] [PMID: 21050868]
[http://dx.doi.org/10.1016/S0041-0101(00)80023-9]
[http://dx.doi.org/10.1016/j.toxicon.2008.08.014] [PMID: 18835291]
[http://dx.doi.org/10.1016/j.peptides.2012.05.005] [PMID: 22617223]
[http://dx.doi.org/10.1016/j.toxicon.2004.05.023] [PMID: 15302528]
[http://dx.doi.org/10.1016/j.bbrc.2004.12.154] [PMID: 15670767]
[http://dx.doi.org/10.1016/j.bbagen.2016.12.022] [PMID: 28012742]
[http://dx.doi.org/10.1107/S0907444908023512] [PMID: 18931410]
[http://dx.doi.org/10.1007/BF00232674] [PMID: 8071987]
[http://dx.doi.org/10.1021/bi050614m] [PMID: 16042391]
[http://dx.doi.org/10.1074/mcp.M700094-MCP200] [PMID: 17855442]
[http://dx.doi.org/10.1016/j.toxlet.2016.12.003] [PMID: 27932254]
[http://dx.doi.org/10.1016/j.ijbiomac.2014.02.058] [PMID: 24632346]
[http://dx.doi.org/10.1016/j.biochi.2011.08.003] [PMID: 21843588]
[http://dx.doi.org/10.1016/0014-5793(72)80621-5] [PMID: 4541477]
[http://dx.doi.org/10.1016/j.toxicon.2017.03.011] [PMID: 28288936]
[http://dx.doi.org/10.1016/S0021-9258(18)99798-X] [PMID: 5950769]
[http://dx.doi.org/10.1016/j.toxicon.2012.12.013] [PMID: 23287726]
[http://dx.doi.org/10.1016/0014-5793(89)80453-3] [PMID: 2721673]
[http://dx.doi.org/10.1016/j.jaci.2018.06.035] [PMID: 30012514]
[http://dx.doi.org/10.1016/j.toxicon.2017.01.014] [PMID: 28115184]
[http://dx.doi.org/10.1042/bj2460795] [PMID: 3500713]
[http://dx.doi.org/10.1042/bj2460799] [PMID: 3500714]
[PMID: 7342600]
[http://dx.doi.org/10.1021/pr060494k] [PMID: 17203976]
[http://dx.doi.org/10.1042/bj3310239] [PMID: 9512485]
[http://dx.doi.org/10.1016/j.toxicon.2009.05.001] [PMID: 19463841]
[http://dx.doi.org/10.1016/0041-0101(96)00023-2] [PMID: 8843580]
[http://dx.doi.org/10.1074/jbc.M110.100479] [PMID: 20164177]
[http://dx.doi.org/10.1074/jbc.M011352200] [PMID: 11344165]
[http://dx.doi.org/10.1074/jbc.M809071200] [PMID: 19208624]
[http://dx.doi.org/10.1016/0163-7258(90)90081-C] [PMID: 2293240]
[http://dx.doi.org/10.1016/0041-0101(88)90248-6] [PMID: 3140426]
[http://dx.doi.org/10.1038/sj.bjp.0705046] [PMID: 12540524]
[http://dx.doi.org/10.1016/j.toxicon.2007.10.008] [PMID: 18061642]
[http://dx.doi.org/10.1016/S0021-9258(18)92826-7] [PMID: 2033037]
[http://dx.doi.org/10.4103/2152-7806.174894] [PMID: 26904371]
[http://dx.doi.org/10.1016/j.ejphar.2008.07.053] [PMID: 18703042]
[http://dx.doi.org/10.1111/j.1476-5381.1990.tb15799.x] [PMID: 2116202]
[http://dx.doi.org/10.1016/j.biologicals.2019.12.002] [PMID: 31839332]
[http://dx.doi.org/10.3390/biom9060205] [PMID: 31141959]
[http://dx.doi.org/10.1016/j.bbrc.2006.12.217] [PMID: 17292326]
[http://dx.doi.org/10.1016/j.ijbiomac.2018.05.230] [PMID: 29870815]
[http://dx.doi.org/10.2174/0929867324666170605091546] [PMID: 28578650]
[http://dx.doi.org/10.3390/toxins11100564] [PMID: 31557973]
[http://dx.doi.org/10.1002/jcp.26428] [PMID: 29319161]
[http://dx.doi.org/10.1016/j.toxicon.2008.12.004] [PMID: 19101583]
[http://dx.doi.org/10.1016/j.etp.2017.01.001] [PMID: 28077256]
[http://dx.doi.org/10.1016/j.ijbiomac.2017.01.064] [PMID: 28093334]
[http://dx.doi.org/10.1016/S2221-1691(13)60042-8] [PMID: 23593597]
[http://dx.doi.org/10.1016/S2221-1691(15)30344-0]
[http://dx.doi.org/10.1016/j.toxicon.2005.09.008] [PMID: 16307769]
[http://dx.doi.org/10.1016/j.toxicon.2017.09.012] [PMID: 28943466]
[http://dx.doi.org/10.1111/j.1365-2672.2006.03161.x] [PMID: 17309613]
[http://dx.doi.org/10.1016/j.toxicon.2009.11.013] [PMID: 19944711]
[http://dx.doi.org/10.1016/j.toxicon.2017.10.001] [PMID: 29024770]
[http://dx.doi.org/10.1016/j.ijbiomac.2015.07.004] [PMID: 26162245]
[http://dx.doi.org/10.1038/labinvest.3700350] [PMID: 16200076]
[http://dx.doi.org/10.1016/j.toxicon.2005.01.013] [PMID: 15777962]
[http://dx.doi.org/10.1016/j.ijbiomac.2016.02.008] [PMID: 26853827]
[http://dx.doi.org/10.1016/j.toxicon.2013.05.017] [PMID: 23747272]
[http://dx.doi.org/10.1186/1471-2334-6-100] [PMID: 16784542]
[http://dx.doi.org/10.1016/j.fob.2015.10.004] [PMID: 26793432]
[http://dx.doi.org/10.1186/s40409-015-0014-y] [PMID: 26042153]
[http://dx.doi.org/10.1016/j.biochi.2008.04.007] [PMID: 18472013]
[http://dx.doi.org/10.1016/j.toxicon.2009.01.003] [PMID: 19708222]
[http://dx.doi.org/10.1016/j.ijbiomac.2015.10.080] [PMID: 26519876]
[http://dx.doi.org/10.1016/j.ijbiomac.2018.06.082] [PMID: 29920366]
[http://dx.doi.org/10.1016/j.biologicals.2009.01.010] [PMID: 19264509]
[http://dx.doi.org/10.1016/j.ijbiomac.2018.09.053] [PMID: 30218735]
[http://dx.doi.org/10.1016/j.toxicon.2016.08.006] [PMID: 27530665]
[http://dx.doi.org/10.1016/S0041-0101(01)00275-6] [PMID: 12175610]
[http://dx.doi.org/10.1186/1472-6882-14-446] [PMID: 25407317]
[http://dx.doi.org/10.1016/j.matbio.2009.09.009] [PMID: 19808093]
[http://dx.doi.org/10.1016/j.mvr.2014.08.006] [PMID: 25173589]
[http://dx.doi.org/10.1016/j.matbio.2012.11.015] [PMID: 23262217]
[http://dx.doi.org/10.1021/bi000428a] [PMID: 10933804]
[http://dx.doi.org/10.1016/j.bbagen.2017.11.019] [PMID: 29196192]
[http://dx.doi.org/10.1016/j.matbio.2007.01.001] [PMID: 17300927]
[http://dx.doi.org/10.1016/j.toxicon.2011.10.012] [PMID: 22079298]
[http://dx.doi.org/10.1016/j.toxicon.2014.08.062] [PMID: 25194746]
[http://dx.doi.org/10.1016/j.cbpb.2011.02.001] [PMID: 21334449]
[http://dx.doi.org/10.1111/j.1742-4658.2011.08262.x] [PMID: 21781279]
[http://dx.doi.org/10.1016/j.bbrc.2016.10.086] [PMID: 28212725]
[http://dx.doi.org/10.1016/j.cbpa.2008.07.007] [PMID: 18804547]
[http://dx.doi.org/10.1016/j.bjhh.2016.03.004] [PMID: 27208571]
[http://dx.doi.org/10.1016/j.bbamcr.2016.09.012] [PMID: 27646922]
[http://dx.doi.org/10.1016/j.freeradbiomed.2005.10.056] [PMID: 16540388]
[http://dx.doi.org/10.1089/ars.2006.8.1765] [PMID: 16987030]
[http://dx.doi.org/10.3892/etm.2017.4287] [PMID: 28565848]
[http://dx.doi.org/10.1038/onc.2008.301] [PMID: 18931691]
[http://dx.doi.org/10.1038/s41598-018-37435-4] [PMID: 30692577]
[http://dx.doi.org/10.1186/1471-2407-12-228] [PMID: 22681760]
[http://dx.doi.org/10.1016/j.cbi.2009.11.027] [PMID: 19954742]
[http://dx.doi.org/10.1016/j.canlet.2014.11.026] [PMID: 25444914]
[http://dx.doi.org/10.1016/j.freeradbiomed.2009.05.024] [PMID: 19482076]
[http://dx.doi.org/10.1038/s41419-019-2035-x] [PMID: 31649256]
[http://dx.doi.org/10.1046/j.1432-1327.1998.2530452.x] [PMID: 9654096]
[http://dx.doi.org/10.1016/S0300-9084(00)01168-8] [PMID: 11086212]
[http://dx.doi.org/10.1016/j.bbalip.2007.12.001] [PMID: 18177747]
[http://dx.doi.org/10.1002/ddr.21456] [PMID: 30255943]
[http://dx.doi.org/10.1006/abbi.2000.1790] [PMID: 10860537]
[http://dx.doi.org/10.1016/j.biochi.2010.07.012] [PMID: 20723574]
[http://dx.doi.org/10.1016/S0167-7799(97)01156-6] [PMID: 9487736]
[http://dx.doi.org/10.1016/j.toxicon.2018.10.306] [PMID: 30395843]
[http://dx.doi.org/10.1186/s40409-015-0044-5] [PMID: 26539212]
[http://dx.doi.org/10.1155/2014/203639] [PMID: 24683541]
[http://dx.doi.org/10.1007/978-94-007-6452-1_13]
[http://dx.doi.org/10.2174/092986609788923266] [PMID: 19689415]
[http://dx.doi.org/10.4161/cam.23840] [PMID: 23563505]
[http://dx.doi.org/10.1016/j.phrs.2020.105327] [PMID: 33276098]
[http://dx.doi.org/10.1016/j.matbio.2009.03.007] [PMID: 19351557]
[http://dx.doi.org/10.1371/journal.pone.0120514] [PMID: 25811661]
[http://dx.doi.org/10.1016/j.micpath.2019.103745] [PMID: 31520734]
[http://dx.doi.org/10.1016/j.bbapap.2013.12.014] [PMID: 24373874]
[PMID: 18676272]
[PMID: 23236583]
[http://dx.doi.org/10.1159/000341446] [PMID: 22854437]
[http://dx.doi.org/10.1016/j.cellimm.2013.07.016] [PMID: 23973876]
[http://dx.doi.org/10.1172/JCI38842] [PMID: 19726870]
[http://dx.doi.org/10.1038/s41467-019-08538-x] [PMID: 30718511]
[http://dx.doi.org/10.1021/ja111110e] [PMID: 21344925]
[http://dx.doi.org/10.1371/journal.pone.0215391] [PMID: 30978253]
[http://dx.doi.org/10.1186/s40409-018-0180-9] [PMID: 30598659]
[http://dx.doi.org/10.5468/ogs.2019.62.4.242] [PMID: 31338341]
[http://dx.doi.org/10.1016/j.jinorgbio.2012.02.012] [PMID: 22465700]
[http://dx.doi.org/10.1007/s13277-014-2146-z] [PMID: 24870598]
[http://dx.doi.org/10.3390/toxins10090346] [PMID: 30158426]
[http://dx.doi.org/10.1016/j.semcancer.2020.05.006] [PMID: 32428714]
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