Title:Physical Characterization and In Vitro Evaluation of Dissolution Rate from Cefpodoxime Proxetil Loaded Self Solidifying Solid SNEDDS
Volume: 19
Issue: 3
Author(s): Pankaj Kumar Sharma*, Vikesh Kumar Shukla and Anoop Kumar
Affiliation:
- Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University Uttar Pradesh, 201303, Uttar Pradesh,
India
Keywords:
Cefpodoxime proxetil, ternary dispersion, tween 80, polyethylene glycol 6000, transcutol, dissolution rate.
Abstract: Background: Cefpodoxime Proxetil (CPD) is a broad-spectrum cephalosporin indicated
in respiratory and urinary tract infections. CPD is a BCS class IV drug with pH-dependent solubility
and has poor bioavailability. This study investigated the challenges of developing ternary components
based on solid SNEDDS of CPD for in vitro dissolution rate enhancement and self-solidifying
behaviour.
Methods: Tween 80, Transcutol and PEG6000 were employed as surfactants, solvents and solidifiers
for a base of ternary components to develop self-solidifying solid SNEDDS, respectively. Ternary
phase diagrams were used to characterize solidifying behaviour of ternary components in different
proportions. S-SNEDDS formulations were drawn on the solidification areas available in the
phase diagram and characterized for IR, XRD, DSC and in vitro drug release in various pH media.
Results: Ternary components for the preparation of self-solidifying solid SNEDDS were selected
based on drug solubility. FTIR and DSC characterization studies ruled out any drug interaction between
CPD and components chosen to prepare S-SNEDDS. CPD was transformed from a crystalline
into an amorphous state in ternary dispersions as revealed from XRD data. Optimized formulation
(S-S 1) demonstrated more than 95% of drug release irrespective of the pH environments of
the medium. Calculation of dissolution efficiency and similarity factors indicate that S SNEDDS resulted
in a higher drug dissolution rate over binary dispersion (p<0.01). The stability studies
showed that the S SNEDDS were stable in performances and CPD assay.
Conclusion: The present investigation provides an alternative approach for enhancing the CPD dissolution
rate using self-solidifying solid SNEDDS exhibited solidification behaviour at ambient
temperature conditions and drug loading, which could be exploited over conventional dosage form.
