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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Solvent-Free Synthesis of Pyrrolo [2,1-α] Isoquinolines via One-Pot Four- Component Reaction

Author(s): Ali Aminkhani* and Sina Sharifi

Volume 19, Issue 3, 2022

Published on: 05 August, 2021

Page: [244 - 249] Pages: 6

DOI: 10.2174/1570178618666210805103552

Price: $65

Abstract

An efficient four-component reaction to synthesize pyrrolo [2,1-a] isoquinolines from malononitrile, aromatic aldehydes, isoquinoline, and cyclohexyl isocyanide under solvent-free conditions is described. In a convenient, simple, and efficient one-pot procedure, the domino Knoevenagel-nucleophilic cycloaddition reaction affords excellent yields of products in less than 1 h.

Keywords: Pyrrolo [2, 1-a]isoquinoline, four-component reactions, isoquinoline, isocyanide, aromatic aldehydes, solvent-free synthesis.

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