摘要
多酚是一类由植物产生的化合物,具有作为强效抗氧化剂的能力。对多酚抗氧化活性的首次研究可以追溯到大约 20 年前,当时首次提出了它们与预防和治疗癌症的关系和意义。后来,在 2000 年代初期,证明了几种多酚的神经保护作用。如今,已经研究了过多多酚的益处,并且它们在多种疾病状况(如癌症、心脏和神经元疾病)中的改善作用得到广泛认可。迄今为止,已经发表了 1000 多篇关于多酚和阿尔茨海默病的论文,描述了这些化合物的抗氧化特性、金属螯合特性和抗聚集行为。本综述的目的是从化学的角度对与阿尔茨海默病的两个重要事件相关的多酚的金属络合机制进行合理化解释:氧化应激和金属离子稳态失衡。为了解决这个问题,我们在此讨论了与阿尔茨海默病有关的几个方面以及参与该疾病治疗的多酚。
关键词: 多酚、铜离子、阿尔茨海默病、抗氧化活性、聚集、淀粉样蛋白。
Current Medicinal Chemistry
Title:Metal Complexation Mechanisms of Polyphenols Associated to Alzheimer’s Disease
Volume: 28 Issue: 35
关键词: 多酚、铜离子、阿尔茨海默病、抗氧化活性、聚集、淀粉样蛋白。
摘要: Polyphenols are a class of compounds, produced by plants, which share the ability to act as potent antioxidants. First investigations on polyphenols’ antioxidant activity are dated almost twenty years ago when their relationship and implication with the prevention and treatment of cancer was proposed for the first time. Later, in the early 2000s, the neuroprotective effects of several polyphenols were demonstrated. Nowadays, the benefits of a plethora of polyphenols have been studied and their ameliorating effects in several disease conditions, like cancer, cardiac and neuronal diseases are widely recognised. More than 1000 papers dealing with polyphenols and Alzheimer’s disease have been published so far, describing the antioxidant properties, the metal chelating features and the anti-aggregating behavior of these compounds. The aim of this review is to rationalize, from a chemical point of view, the metal complexation mechanisms of polyphenols related to two significant events of Alzheimer’s disease: oxidative stress and metal ion dyshomeostasis. In order to address this issue, we have herein discussed several aspects implicated in Alzheimer’s disease and polyphenols involved in the treatment of the disease.
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Metal Complexation Mechanisms of Polyphenols Associated to Alzheimer’s Disease, Current Medicinal Chemistry 2021; 28 (35) . https://dx.doi.org/10.2174/0929867328666210729120242
DOI https://dx.doi.org/10.2174/0929867328666210729120242 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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