Title:Nanomaterials of Natural Bioactive Compounds for Wound Healing: Novel Drug Delivery Approach
Volume: 18
Issue: 10
Author(s): Vinay Kant*, Pooja Kumari, Dhaval K. Jitendra, Munish Ahuja and Vinod Kumar
Affiliation:
- Department of Veterinary Pharmacology & Toxicology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, India
Keywords:
Bioactive compounds, polymer, nanoparticles, drug delivery, controlled release, wound healing.
Abstract: Wound healing is a biological phenomenon of the body involving sequential biochemical
processes that are primarily involved in restoring the cellular integrity of the organ. The market
related to wound-care products has extensively been expanded and crossed over fifteen billion US
dollars, along with twelve billion US dollars for treating wound scars. Different bioactive compounds
have shown their various pharmacological actions including wound healing activity. Natural
bioactive agents have gained much attention in wound management due to their beneficial nature
of possessing least side effects. Some of the bioactive compounds which have shown pronounced
wound healing potentials,such as curcumin, quercetin, lawsone, resveratrol, aloe vera, astragaloside,
essential oils, growth factors, andrographolide, bilirubin, etc. Most of the natural bioactive
agents have limited applicability in clinical practices due to poor aqueous solubility, fast degradation
rate and low bioavailability. These problems have been overcome in last few years by encapsulating
them into nano-formulations. The nanomaterials of bioactive agents offer discrete advantages
like high surface area to volume ratio and nanoscale size offering alternations in physical and
chemical properties. These nanomaterials also have sustained controlled release delivery, which
seems to be very effective for the lengthy process of wound healing. Many investigations by the
global researchers have focused on the emergence of nanomaterials in wound healing applications.
In the present review, different natural bioactive agents in the form of nanoformulations have been
discussed for wound healing potentials.
