Title:Asymmetric Organocatalytic Syntheses of Bioactive Compounds
Volume: 19
Issue: 1
Author(s): Estibaliz Sansinenea and Aurelio Ortiz*
Affiliation:
- Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, México
Keywords:
Organocatalysis, organocatalytic process, organocatalytic cascade reactions, asymmetric synthesis, natural products, stereoselectivity, catalyst.
Abstract: Background: The total syntheses of complex natural products have evolved to include new
methodologies to save time, simplifying the form to achieve these natural compounds.
Objectives: In this review, we have described the asymmetric synthesis of different natural products and
biologically active compounds of the last ten years until the current day.
Results: An asymmetric organocatalytic reaction is a key to generate stereoselectively the main structure
with the required stereochemistry.
Conclusion: Even more remarkable, the organocatalytic cascade reactions, which are carried out with
high stereoselectivity, as well as a possible approximation of the organocatalysts activation with substrates
are also described.