Title:Current Pathogenesis of Alzheimer’s Disease and Plants Derived Neuroprotective Phytoconstituents: A Comprehensive Review
Volume: 10
Author(s): Anil K. Pradhan, Bimala Tripathy*, Bimalendu Chowdhury, Sasmita K. Acharjya and Rajaram Das
Affiliation:
- Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur-760010, Ganjam, Odisha,India
Keywords:
Amyloid beta, amyloid precursor protein, tau hyperphosphorylation, oxidative stress, neuroprotection, phytochemicals.
Abstract:
Background: The exact pathogenesis of Alzheimer’s disease is still a matter to debate. Currently
there is no reliable therapy established for Alzheimer’s disease. However, several pieces of evidence
suggest that the use of plant based phytoconstituents mainly delays the onset of Alzheimer’s
disease. So, in this review, we collect information about the cause of Alzheimer’s disease hypothesis
and the neuroprotective effect of phytoconstituents.
Objective: This review paper aimed to analyze the current pathogenesis of Alzheimer’s disease and
therapeutic effect of plant phytoconstituents that play a vital role in neuroprotective and antistress activities
in Alzheimer’s disease and other neurodegenerative disorders.
Methods: The source of literature review obtained from Scopus, Science Direct, PubMed, Web of
Science database, and journal by using Alzheimer’s pathogenesis, neuroinflammation, oxidative
stress, amyloid beta, flavonoids, alkaloids are an important part of these review research.
Results: The current review explored different types of pathogenesis involved in Alzheimer’s disease
and the role of phytoconstituents in its treatment. The collected information showed that plant based
constituents inhibit the major cause of Alzheimer’s disease related to amyloid beta, tau protein, oxidative
stress, neuroinflammation, etc.
Conclusion: The study provides the clue for the investigation of eminent bioactive constituents may
serve as an alternative candidate against Alzheimer’s disease and other neurodegenerative disorders.