Title:No Association of MicroRNA-146a rs2910164 Polymorphism and Risk of Primary Gout Development in Chinese Han Populations: A Case-control Study
Volume: 17
Issue: 4
Author(s): Yu-Feng Qing*, Quan-Bo Zhang, Fei Dai, Yu-Qin Huang, Jian-Xiong Zheng, Yi-Ping Tang, Zeng-Rong Dong and Shun-Bing Wang
Affiliation:
- Research Center of Hyperuricemia and Gout, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000,China
Keywords:
miR-146a, rs2910164, polymorphisms, gout, susceptibility, hyperuricemia.
Abstract:
Background: Previous studies demonstrated that MicroRNA-146a (miR-146a) plays an
important role in the regulation of autoinflammatory diseases including primary gout. The G/C polymorphism
(rs2910164) in the precursor sequence of miR-146a caused its stem region to change
from G: U to C: U,which can contribute to the susceptibility of human diseases. However, no genetic
relevance studies of miR-146a gene polymorphisms to gout have been reported by now.
Objective: The purpose of this study was to analyze the association between the miR-146a
rs2910164 genetic polymorphism and the susceptibility of the Chinese Han population to primary
gout.
Methods: 1130 Chinese Han participants (including 606 primary gout patients and 524 gender and
age-matched healthy control subjects) were recruited and the 5'exonuclease TaqMan® technology
was used to perform miR-146a rs2910164 genotyping.
Results: After statistical analysis, no significant differences were observed between gout patients
and healthy controls in genotype and allele frequency.
Conclusion: Our results indicate that there is no evidence for the involvement of the miR-146a
rs2910164 polymorphisms in susceptibility to primary gout in the Chinese Han population.
